Acknowledgments This study was

2019-07-01

Acknowledgments This study was supported by the National Natural Science Foundation of China (Nos. 81273501 and 81470378). Introduction Sudden cardiac death (SCD) is a tragic event and the aftermath is devastating to the surviving family and community. SCD occurs in nearly 400,000 cases every year in the US [1]. In adult populations, cardiomyopathies and cardiac ion channelopathies, along with coronary JQ1 disease (CHD), are the most common conditions that predispose patients to SCD. According to recent epidemiological studies of SCD in Western countries, CHD, cardiomyopathies, and ion channelopathies are diagnosed in ~75%, 10–15%, and 1–2% of the SCD cases, respectively [2]. In Japan, approximately 50,000 new cases of SCD are diagnosed every year [3].

Paying now rather than

2019-06-29

Paying now rather than forever has never been as relevant as a global health solution to the HIV pandemic than in 2013. The relative success of the ongoing replenishment session for the Global Fund is a positive signal, although still insufficient considering the evidence-based targets that are set for the coming years.

A decreasing trend in

2019-06-28

A decreasing trend in CRT-D implantation has been reported recently, based on the database from the National Inpatient Sample in the USA [20]. They found that advancing age and an increasing comorbidity burden were associated with a reduced likelihood of CRT-D, and speculated that the decline in CRT-D implantation may reflect the intersection of high-comorbidity patients and the expectation of reduced ICD benefit in this patient population [20].

VV optimization From the foregoing discussion it is

2019-06-27

VV optimization From the foregoing discussion, it is clear that AV delay programming to ensure ventricular preexcitation with optimal LV diastolic filling and systolic function is complex, and the optimal method that translates into improved patient outcomes is uncertain. These issues are even more apparent in studies of VV optimization. The landmark trials of CRT in Cocktail failure all demonstrated a benefit of CRT using simultaneous BiV pacing in conjunction with AV delay optimization [3,5,7,9,10,44].

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2018-07-29