• Hepatocyte proliferation is accompanied by

  2019-07-15

  

  Hepatocyte proliferation is accompanied by changing gene expression [1,2]. as two of the three estrogen receptors are transcription factors: Estrogen Receptor alpha (ERα) and ERβ [[3], [4], [5]]. The most potent ligand estradiol, binds to ERα/ERβ and exerts changing cognate gene transcription [5]. O

• In this study we further investigate how

  2019-07-15

  

  In this study, we further investigate how STAT3 integrate to the core regulatory circuit in ESC pluripotency and differentiation, and identify Mettl8 as a downstream target of STAT3 in mESCs. We discover the role of METTL8 as a negative regulator of JNK signaling in stem cells. Our results provide i

• br Materials and methods br Results and discussion br Conclu

  2019-07-15

  

  Materials and methods Results and discussion Conclusions Acknowledgements This work was supported financially by the LIAONING S&T Project (No. 20180550107) and Basic Scientific Research Funds of DLNU (0918110143). Introduction Since 1970s, numerous artificial mimetic enzymes have bee

• PP242 br Transparency document br Main Text The centrosome i

  2019-07-15

  

  Transparency document Main Text The centrosome is a non-membrane-bound organelle found in most animal cells. It has several important functions, including control of cilia formation, microtubule organization and nucleation, spindle assembly and transport of organelles and vesicles. Centrosomes

• In the frontal cortex

  2019-07-13

  In the frontal cortex, the present study found a relationship between working memory performance and activated Erk2 expression for the E2-only group, where animals that tended to perform better on the WMC measure tended to have higher activated Erk2 expression.

• Currently, multiple clinical trials of

  2019-07-12

  Currently, multiple clinical trials of CSF-1/CSF-1R-targeting agents in combination with standard treatment modalities and immunotherapies are underway (Table 1). In particular, results for combinations with checkpoint blockade inhibitors and other immunotherapeutic approaches are eagerly awaited.

• To elucidate the potential mechanism

  2019-07-11

  To elucidate the potential mechanism underlying osteosarcoma cell growth decrease by CDK4 inhibition, flow cytometry analysis was used to determine Pomalidomide and apoptosis in human osteosarcoma cells after palbociclib treatment. The results showed that osteosarcoma cells were arrested in G1 phase of the cell cycle after CDK4 inhibition by palbociclib.

• Stem cell–based therapies In the

  2019-07-10

  Stem cell–based therapies In the previous years, excessive efforts have been conducted to induce the least aggression and more efficient sources of human cardiomyocytes for different application, particularly for myocardial regeneration. The pluripotent stem cell seems to be an appropriate candidate, due to its proliferate properties and its ability to distinguish into various cell types including cardiomyocytes [7].

• LVDP values of ~80% at the end of reperfusion

  2019-07-09

  LVDP values of ~80% at the end of reperfusion. L-NAME treatment did not modify the contractility detected in ischemic control hearts but annulled the actions of BZ acquiring LVDP values up to 40% (Fig. 4 A). A similar pattern was observed when +dP/dtmax was analysed (Fig. 4 B). LVEDP, as an index of diastolic stiffness, was approximately 13 mmHg at the end of the stabilization period.

• Introduction Progesterone, also known as P4

  2019-07-08

  Introduction Progesterone, also known as P4, is a steroid hormone acting as a key component in the complex regulation of female reproductive function. P4 plays major physiological roles in the uterus and ovary by releasing mature oocytes helping in implantation and maintenance of pregnancy, as well as in the mammary gland in preparation for milk secretion and suppression of milk protein synthesis before parturition. In the brain, this hormone mediates signals required for sexually responsive behavior, and also supports modulation of bone mass [1]. The ovary is the main site of synthesis and secretion of P4 in the mammal and gives rise to cyclic fluctuations in the levels of circulating hormone. Measurement of P4 in serum or plasma constitutes a routine feature in the clinical investigation of reproductive function, where the changes in its concentration can be used to detect the occurrence of ovulation and to indicate the end of the fertile period. However, an accurate assessment of hormonal status often needs repetitive venipuncture and, thus, development of less invasive methods are strongly encouraged.

• The promoter regions of all MdDGKs examined

  2019-07-05

  The promoter regions of all MdDGKs examined here included many hormone-responsive and stress-responsive elements, such as ABRE, MBS, TC-rich repeats, HSE, and LTR. Despite assumptions about how those promoters might control expression in response to environment stimuli, we found several exceptions. For example, MdDGK1 contained no MBS even though its expression was induced by drought treatment.

• Introduction Natural killer (NK) cells

  2019-07-04

  Introduction Natural killer (NK) cells have an unique ability to directly lyse transformed, virus-infected or stressed cells without prior sensitization or major histocompatibility complex (MHC) class I restriction [1], [2]. They were initially defined and shown to be important effectors of the innate immune system and are included in the recently redefined family of innate lymphoid cells (ILC) as type 1 ILC [3].

• Cytochromes P450 (CYP 450) are

  2019-07-03

  Cytochromes P450 (CYP 450) are a superfamily of hemoproteins containing a heme cofactor, which are widely distributed in animals, plants and microbes (Hannemann et al., 2007). CYP450 exhibits a variety of biological functions including biotransformation of drugs, detoxification of endogenous and xenobiotic components through hydroxylation, bio-oxidation and reduction (Guengerich, 2001; Hannemann et al., 2007; Zanger and Schwab, 2013). Previous reports has demonstrated that the human enzyme CYP1A2 could metabolically activate OA (Hashizume et al., 2009). Congruently, biochemical assays showed that CYP3A4 and CYP3A5 converted OA into other derivatives (Guo et al., 2010).

• Discussion The ubiquitin system has

  2019-07-02

  Discussion The ubiquitin system has in recent years become an exciting area for drug discovery (Cohen and Tcherpakov, 2010), as multiple enzymatic steps within the ubiquitylation process are druggable. The potential of targeting the ubiquitin-proteasome pathway was first demonstrated in 2003 by the approval of the proteasome inhibitor bortezomib (Velcade; Millennium Pharmaceuticals) for use in multiple myeloma. While proteasome inhibition is a broad intervention affecting general survivability, E3 ubiquitin ligases and DUBs (Ritorto et al., 2014)

• Acknowledgments This study was

  2019-07-01

  Acknowledgments This study was supported by the National Natural Science Foundation of China (Nos. 81273501 and 81470378). Introduction Sudden cardiac death (SCD) is a tragic event and the aftermath is devastating to the surviving family and community. SCD occurs in nearly 400,000 cases every year in the US [1]. In adult populations, cardiomyopathies and cardiac ion channelopathies, along with coronary JQ1 disease (CHD), are the most common conditions that predispose patients to SCD. According to recent epidemiological studies of SCD in Western countries, CHD, cardiomyopathies, and ion channelopathies are diagnosed in ~75%, 10–15%, and 1–2% of the SCD cases, respectively [2]. In Japan, approximately 50,000 new cases of SCD are diagnosed every year [3].

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