• The nucleus accumbens is a critical

  2021-03-23

  

  The nucleus accumbens is a critical locus for ER/mGluR signaling in the context of addiction ER/mGluR signaling is regulated by caveolin proteins and palmitoylation Because of the vast implications of ER/mGluR association, it is important to understand what regulates their interaction. Such regu

• Our observation that nuclear but not cytoplasmic EP expressi

  2021-03-23

  

  Our observation that nuclear, but not cytoplasmic EP4 expression is associated with different outcomes is interesting. In breast cancer, using the same methods, we did not detect EP4 in the nucleus of malignant alln receptor whereas cytoplasmic EP4 was commonly observed [13]. While G protein-coupled

• The discoidin domain receptors DDR and

  2021-03-23

  

  The discoidin domain receptors, DDR1 and DDR2, are receptor tyrosine kinases (RTKs) that are stimulated by collagen in the extracellular matrix (ECM). Unlike most other RTKs, they form ligand-independent stable dimers that are non-covalently linked. This ECM activation induces receptor phosphorylati

• br Orthotopic liver transplantation OLT is the

  2021-03-23

  

  Orthotopic liver transplantation (OLT) is the only curative therapy available for patients with end-stage liver disease. The surgical procedure of liver transplantation inherently involves cold ischemia during graft preservation , followed by reperfusion of the transplanted graft which results in

• Interestingly our analyses of human PBMCs using a

  2021-03-23

  

  Interestingly, our analyses of human PBMCs using a monoclonal antibody against EBI2 showed that the expression pattern of human EBI2 is largely overlapping with that in mice. Especially Th17 Dequalinium Chloride showed homogeneous high expression of EBI2 compared with Th1 cells, which contained a f

• WES and validation by Sanger

  2021-03-23

  

  WES and validation by Sanger sequencing in PNGS-252 revealed an apparent homozygous c.4C>G missense alteration (GenBank: NM_014176.3), resulting in the amino beta lapachone mg substitution p.Gln2Glu (Figure 1A). This mutation must be very rare, because this is not listed in the NHLBI Exome Sequencin

• br Material and methods br Results and discussion

  2021-03-23

  

  Material and methods Results and discussion Conclusions Acknowledgements S. De thanks DST, New Delhi for generous grant of the SERC Fast Track Scheme No. SR/FT/CS-057/2008. R. Kundu thanks the University of Kalyani for financial assistance. We are grateful to Prof. K. Bhattacharyya of IA

• br Acknowledgement br Introduction Human dihydroorotate dehy

  2021-03-23

  

  Acknowledgement Introduction Human dihydroorotate dehydrogenase (hDHODH), a flavin-dependent mitochondrial enzyme involved in de novo (+)-Usniacin biosynthesis, is a validated therapeutic target for the treatment of autoimmune diseases such as rheumatoid arthritis and cancer [1], [2], [3]. Le

• Collagen X is a homotrimeric molecule of three

  2021-03-23

  

  Collagen X is a homotrimeric molecule of three α1(X) chains (Mr 59 kDa) comprising a 45 kDa triple-helical domain flanked by an N-terminal (NC2) and a larger C-terminal (NC1) non-collagenous domains (Shen, 2005). In the hypertrophic ECM, collagen X most likely forms an extended hexagonal network, as

• hUcn II influence on MAP is mediated by

  2021-03-22

  

  hUcn II influence on MAP is mediated by the activation of CRF2 receptors. In vitro binding studies established that hUcn II is a selective ligand for CRF2 receptors with a slightly higher affinities for CRF2β compared with CRF2α and low or no affinity for CRF1 receptor [13], [19], [24]. Recent in vi

• Khan et al investigatedAnomalin a pyranocoumarin constituent

  2021-03-22

  

  Khan et al. investigatedAnomalin 44, a pyranocoumarin constituent of S. divaricata, which exhibits potent anti-inflammatory activity. The anomalin 44 dose-dependently inhibited inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) mRNA and protein expression in LPS-stimulated RAW 264.7

• Abbas et al studied the mitigation

  2021-03-22

  

  Abbas et al. studied the mitigation of ASR in their corresponding study by incorporating RHA [1]. These researchers used Ordinary Portland Cement (OPC), four different percentages (i.e., 10%, 20%, 30% and 40% by weight of OPC) of RHA and reactive aggregate (sand from Dolomite-limestone rock) in thei

• EC barrier dysfunction triggered by inflammatory mediators i

  2021-03-22

  

  EC barrier dysfunction triggered by inflammatory mediators involves more than one mechanism, explaining the partial attenuation of EC barrier compromise obtained with PKA and Epac activators. PKA-dependent phosphorylation of vasodilator-stimulated phosphoprotein (VASP) has been shown to make a posit

• At first cartilage damage in osteoarthritis

  2021-03-22

  

  At first, cartilage damage in osteoarthritis reflects the loss of proteoglycan and collagen network that increases the swelling of tissues. The incremented expression of DDR2 receptor has also co-related with the depletion of cartilage in surgically induced OA model [8]. Osteoarthritis, a degenerati

• thiotepa receptor br RING dimerization RING type domains are

  2021-03-22

  

  RING dimerization RING-type domains are found in many different structural contexts. While many exist as single-chain thiotepa receptor (Fig. 3A), a notable feature of RING-type E3s is their tendency to form homodimers and heterodimers (Fig. 3C–F). Homodimeric RING-type E3s include cIAP, RNF4, B

15041 records 676/1003 page Previous Next First page 上5页 676677678679680 下5页 Last page