• br Development of calibrators and controls

  2021-12-08

  

  Development of calibrators and controls for DiXaIs Method validation and comparison with reference technique (LC:MS) At this stage, anti-Factor Xa bioassays can be established for reliably measuring DiXaI concentrations in plasma, with the available appropriate drug specific calibrators and co

• br Introduction Thrombosis is one of the leading causes

  2021-12-08

  

  Introduction Thrombosis is one of the leading causes of deaths in the cardiovascular diseases such as myocardial infarction (MI), unstable Sildenafil Citrate mg and acute coronary syndrome (ACS) in developed countries [1], [2]. It is estimated that venous thromboembolism (VTE) afflicts about 1 m

• br Acknowledgments This study was financially supported by N

  2021-12-07

  

  Acknowledgments This study was financially supported by National Science Center Poland grant No DEC-2011/02/A/NZ4/00031 (KKK), Jagiellonian University Medical College (Poland) grants: K/ZDS/007130 (SM) and K/ZDS/007131 (SM), COST Action CA15135 (DŁ, HS, KKK) and DFG INST 208/664-1 FUGG (HS). Than

• A more quantitative view of

  2021-12-07

  

  A more quantitative view of kinase specificity suggests a continuum of phosphorylation rates for the various substrates of a particular kinase (Figure 4A). Such differences in ‘substrate quality’ can arise from variations in phosphorylation site or docking sequences and may explain why the timing or

• In mice iNKT cells are most frequent among liver

  2021-12-07

  

  In mice, iNKT cells are most frequent (20–30%) among liver T lymphocytes, while they only constitute 0.4–1% of the total T cells in thymus, bone marrow, spleen, lymph node, and intraepithelial lymphocytes. In humans, iNKT cells constitute approximately only a 0.1–0.2% of the peripheral blood T lymph

• (±)-Epibatidine receptor br Materials and methods br Re

  2021-12-07

  

  Materials and methods Results and discussion Conflict of interest Introduction In the presence of continuous and excessive levels of nutrients, adipocytes become hypertrophic and release several pro-inflammatory adipocytokines such as interleukin-6 (IL-6), monocyte chemoattractant protei

• br Materials and methods br Results br Discussion Heart

  2021-12-07

  

  Materials and methods Results Discussion Heart hypertrophy is initially physiological to compensate for the loss of heart functions. However, sustained stresses lead to a pathological status, in which myocardium becomes stiffened by interstitial fibrosis and thereby diastolic dysfunction in

• br Results and discussion br Conclusion

  2021-12-07

  

  Results and discussion Conclusion In conclusion, we designed and synthesized a novel series of thiosemicarbazide-1,2,3-triazole hybrids 10a-o. Further, α-glucosidase inhibitory activity of the synthesized compounds 10a-o was evaluated. The obtained results showed that all the synthesized thios

• br Central control of GI

  2021-12-07

  

  Central control of GI ghrelin secretion The CNS communicates with the GI tract through the vagus nerve originating in the DMV and sympathetic spinal afferents emanating from the thoracic spinal chord (Bray, 2000). The cells that secrete peripheral ghrelin are under direct control of these two pat

• We are aware that the classical biochemical view is centered

  2021-12-07

  

  We are aware that the classical biochemical view is centered on the local concentrations of specific ion and molecules rather than on cell electric potentials. However, important downstream processes can be influenced by acting locally on these potentials because they regulate the conductance of the

• br Materials and methods br Results

  2021-12-06

  

  Materials and methods Results Conclusions In general, the drug design process is very laborious, expensive and prone to errors. Various computational methods including docking and algorithms based on molecular dynamics and/or quantum chemistry can help considerably at the early stage of str

• Nonetheless several questions remain to be answered about FA

  2021-12-06

  

  Nonetheless, several questions remain to be answered about FAAH inhibition to address cannabis use disorder. The trial was of short duration (4 weeks), whereas most clinical trials in this field have been for 8–12 weeks., , , Although motivational deficits are commonly present in cannabis users and

• br Obesity tips to a systematic

  2021-12-06

  

  Obesity tips to a systematic failure in the overall metabolic regulation; it is a major global health problem and is linked to several metabolic diseases such as (T2D) (see ), (NAFLD), and cardiovascular disorders. The prevalence of such metabolic disorders has increased dramatically worldwide ,

• UV vis spectra of hsGC

  2021-12-06

  

  UV–vis spectra of hsGC proteins were recorded with an HP8453 UV–vis spectrophotometer at 20°C. The corresponding ferrous, CO-bound and NO-bound species were prepared with the similar published procedure [7], [15]. The heme transfer reactions were performed by a UV–vis spectrometer with kinetic mode

• Having identified initial leads and

  2021-12-06

  

  Having identified initial leads and (), further lead optimization was initiated on B- and C-rings to afford compounds with improved potency. Initial set of substituted imidazole-biphenyl-carboxylic ACY-241 derivatives – and () were evaluated for GSNOR potency. Among this, fluoro, methyl, chloro

14993 records 518/1000 page Previous Next First page 上5页 516517518519520 下5页 Last page