• One clue to how evolution has solved such spatiotemporal

  2021-12-23

  

  One clue to how evolution has solved such spatiotemporal challenges comes from studies revealing that lymph node (LN) organization is more complex than originally presumed, suggesting that steady-state microanatomical features are crucial for effective immune responses (reviewed by Qi et al., 2014).

• lactacystin After initial validation of the ability of

  2021-12-23

  

  After initial validation of the ability of Ad5-Cre virus to express Cre recombinase protein in glial cells in vitro and in vivo, we employed this virus to induce site-specific deletion of our target GlyT1 in the thalamus, through injection of the cKO GlyT1 mice. This transgenic line was constructed

• Recent research reveals that human alkyladenine DNA glycosyl

  2021-12-23

  

  Recent research reveals that human alkyladenine DNA glycosylase (hAAG) is an important protein enzyme which can specifically recognize and excise a variety of alkylated purines and deoxyinosine from DNA [12]. hAAG plays pivotal roles in maintaining genomic integrity, and it is involved in carboxypep

• br Investigations br Genetics GLUT is a membrane

  2021-12-23

  

  Investigations Genetics GLUT1 is a membrane-bound glycoprotein that provides base-rate glucose transport across blood-tissue barriers. It is constituitively expressed in erythrocytes, KC7F2 synthesis microvessels and astroglia. The gene exclusively associated with GLUT1 is SLC2A1, located on c

• In terms of stimulation oxytocin dopamine noradrenaline adre

  2021-12-23

  

  In terms of stimulation, oxytocin, dopamine, noradrenaline, adrenaline and glucagon have all been reported to increase ghrelin secretion (Mundinger et al., 2006, Iwakura et al., 2011, de la Cour et al., 2007, Gagnon and Anini, 2013). Stimulatory effects on ghrelin secretion have also been observed w

• Creatinine br Conflict of interests br Acknowledgements This

  2021-12-22

  

  Conflict of interests Acknowledgements This work was supported by the National Institutes of Health grants HD058577 and ES01678 to Kirill Kiselyov. We thank Sreeram Ravi for technical support. We also thank Mike Myers at the University of Pittsburgh Cancer Institute Flow Cytometry Facility.

• In addition to Rabs several proteins have been shown

  2021-12-22

  

  In addition to Rabs, several proteins have been shown to interact with Rabphilin3a, for instance the GluN2A subunit of the NMDA receptor, PSD-95 ([56,57] and references therein), Rabaptin-5, α-actinin [16] and SNAP-25 [21,23,41,61]. Only the latter has been reported to participate in the AR. Explori

• br Acknowledgments The authors gratefully acknowledge the fi

  2021-12-22

  

  Acknowledgments The authors gratefully acknowledge the financial support of this study by STCU Project 6052 “Enzyme multibiosensor system for renal dysfunction diagnosis and hemodialysis control”. Furthermore, this study was supported by NASU in the frame of Scientific and Technical Program “Sens

• In vitro studies suggest that

  2021-12-22

  

  In vitro studies suggest that the increase in Hx activity seen in normal pregnancy may contribute to the down-regulation of the vascular expression of Angiotensin II receptor 1 thereby promoting a relaxed and dilated maternal vascular bed [25]. It has further been suggested that the decreased Hx act

• TP-0903 The overall characteristic of RNA profile of

  2021-12-22

  

  The overall characteristic of RNA profile of Leydig cell is still a mystery. Variation in total RNA will cause subsequent difference in protein expression and phenotypic modulation [16]. In this study, we used a murine nicotine exposure model coupled with next generation RNA sequencing (NGS) and fou

• Three main mechanisms have been proposed for the secretion

  2021-12-22

  

  Three main mechanisms have been proposed for the secretion of active forms of hedgehog ligands: first, construction of a multimeric molecule with lipid moieties placed on the inside, making a soluble Hh protein which can diffuse from the membrane; second, function of dispatched proteins through pack

• br Concluding Remarks and Future

  2021-12-22

  

  Concluding Remarks and Future Perspectives Our understanding of substrate targeting mechanisms utilized by kinases has grown tremendously in the past few years, but challenges still remain in relating these mechanisms to the organization of complex signaling networks. Substrate prediction based o

• Many studies support that the

  2021-12-22

  

  Many studies support that the increase of P4 improves embryonic survival and reduces embryonic losses in ruminants [6,[18], [19], [20]]. However, experimental results are variable, contradictory and often inconclusive results. Certain studies showed that administration of GnRH or hCG after artificia

• Abnormal expression and higher activity

  2021-12-22

  

  Abnormal expression and higher activity of GLO I have been detected more in various tumor nrf2 inhibitor than in normal cell samples., , , , , , , Among cancer cell lines, lung carcinoma cells frequently showed higher GLO1 activity. Human NSCLC cell line NCI-H522 cells possess high activity and expr

• br Materials and methods br Results br Discussion The

  2021-12-22

  

  Materials and methods Results Discussion The redox domain that spans the region between amino muscarinic receptor antagonists positions 35 and 127 of the major human AP endonuclease, APE1, regulates the sequence-specific DNA binding of various transcription factors [[52], [85]]. The existe

15045 records 512/1003 page Previous Next First page 上5页 511512513514515 下5页 Last page