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br Materials and methods br Results Using an
2021-12-14
Materials and methods Results Using an 84 gene Th1-Th2-Th3 cytokine profile, 17 genes were significantly up-regulated in PBMC one week post-marathon compared to pre-marathon samples (Table 1). Eight genes were down-regulated among various subjects but none consistently enough to achieve statis
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vasopressin receptor antagonists The advent of next generati
2021-12-14
The advent of next-generation sequencing (NGS) has shown that considerable variation in human genome is still undiscovered and therefore a considerable number of rare variations that are related to disease susceptibility may still be unknown. NGS has allowed to strengthen the association between los
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The differentially expressed proteins during
2021-12-14
The differentially expressed proteins during somatic embryogenesis are described as the proteins that are induced by oxidative stress and respond to higher cell division activity including ascorbate peroxidase, dehydroascorbate reductase, glutathione transferase and mitochondrial manganese superoxid
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Interestingly mGlu and mGlu receptors differ notably by
2021-12-14
Interestingly, mGlu2 and mGlu3 receptors differ notably by their cellular distribution. Whereas mGlu2 receptors are mostly neuronal, mGlu3 receptors are expressed both in glia and in neurons. In neurons, mGlu3 receptors are present at the post-synapse and in presynaptic elements (Tamaru et al., 2001
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br Genetic rescue of GluR A dependent spatial working
2021-12-14
Genetic rescue of GluR-A-dependent spatial working memory Spatial working memory performance in GluR-A−/− mice can be restored by the forebrain-specific MC 1568 of GluR-A subunits labeled with green-fluorescent protein (GFP) on an otherwise GluR-A knockout background (Schmitt et al., 2005). This
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To evaluate SLC A abundance after transfection we performed
2021-12-14
To evaluate SLC45A1 abundance after transfection, we performed western blots. Transfected COS-7 KU-0059436 were lysed and separated for membrane fraction. Equal amounts of proteins from membrane fractions were resolved by SDS-PAGE, transferred to a nitrocellulose filter, and immunoblotted with an a
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Many studies support that Gli transcription factors are not
2021-12-14
Many studies support that Gli transcription factors are not solely regulated by Hh/smo signaling but are also influenced by crosstalk with other pathways, such as RAS, PI3K/AKT, transforming growth factor-b/SMAD, PKC, or extracellular signal-regulated kinase pathways which are downstream and indepen
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On the other hand with the
2021-12-14
On the other hand, with the exception in muscle tissue, cGalR2 and cGalR2-L transcripts were also found to be widely distributed among the peripheral tissues at different levels (Fig. 2). The precise functions of cGalR2 and cGalR2-L in these peripheral tissues remain to be established, however, thei
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FPR activation stimulates multiple signal transduction pathw
2021-12-14
FPR1 activation stimulates multiple signal transduction pathways responsible for various neutrophil functions, such as adhesion, chemotaxis, phagocytosis, Curcumol mg of secretory granules, and superoxide anion radical (O2) production, which contribute to the physiological inflammatory response ass
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Oltipraz has been shown to inhibit the growth
2021-12-13
Oltipraz has been shown to inhibit the growth of HCC Pasireotide and is being evaluated in clinical trials as a potential anti-cancer drug for HCC (Mann et al., 2009; Piton et al., 2005; Yates and Kensler, 2007). The present observation that pre-treatment of tumorigenic liver cells with oltipraz cau
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br Introduction Given the growing acceptance
2021-12-13
Introduction Given the growing acceptance of ergothioneine (ET) as a biologically important agent with potential therapeutic applications [[1], [2], [3], [4]] it is increasingly important to clearly establish the role of the organic cation transporter (novel) type 1 (OCTN1). OCTN1 was discovered
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In respect of clinical development Takeda
2021-12-13
In respect of clinical development Takeda has pioneered the field with the GPR40 agonist TAK-875 or fasiglifam (Figure 2A), which in phase-II studies decreased HbA1c as efficiently as sulfonylurea without signs of hypoglycemia [24]. This was obtained with surprisingly little effect on systemic insul
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The manner in which various residue side
2021-12-13
The manner in which various residue side chains are oriented in the active site of HsHxKIV was a driving factor for why glucosamine analogues could not bind, as we previously proposed [16]. These compounds would have difficulty managing access into the active site based on residue P153 in addition t
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Regulation of Gja involves a member
2021-12-13
Regulation of Gja4 involves a member of the wingless-type MMTV integration site family, WNT4. Mice deficient in Wnt4 had reduced (30%) expression of GJA1 compared to WT mice [40]. It is thought that WNT signaling regulates GJA1 expression and GJIC in granulosa transcription factor by modulating bet
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br Conclusions In this study we discovered that the
2021-12-13
Conclusions In this study, we discovered that the G-quadruplex (Q1) formed by S1 sequence in the upstream region of the transcription start site of c-Myb gene functioned as a positive transcriptional regulator, which was different from the most cases that G-rich sequences functioned to impair the
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