• Generally speaking the regulation of GnIH on gonadotropins s

  2022-07-11

  

  Generally speaking, the regulation of GnIH on gonadotropins synthesis and release, although controversial, could be direct and/or indirect via GnRH, among others peptides. In this sense, different scenarios have been reported in vertebrates. In mammalian and avian species, GnIH fibers reach the med

• A further generally applicable approach for

  2022-07-11

  

  A further generally applicable approach for the synthesis of N-linked glycopeptides involves the convergent Lansbury aspartylation of glycosylamines. Here, the detrimental formation of aspartimides during the activation of the side chain aspartate can be prevented through the use of Ser/Thr pseudopr

• We were able to obtain several crystalline forms

  2022-07-11

  

  We were able to obtain several crystalline forms of CHAV Gth. The first one corresponded to the post-fusion conformation [14]. The comparison of this structure with that of VSV-Gth post-fusion conformation revealed that the PHD is the most divergent domain, with the largest differences confined to t

• PTMs have been shown to influence transporter kinetics both

  2022-07-11

  

  PTMs have been shown to influence transporter kinetics, both directly and indirectly (Xu & You, 2017). They do not just regulate the innate structure-function relationship driven by a transporter's global architecture, but rather are also able to regulate this relationship down to the resolution of

• Peripheral injury or disease induced alterations in synaptic

  2022-07-11

  

  Peripheral injury- or disease-induced alterations in synaptic efficacy occur not only at the first synapse made by the primary nociceptive afferents in the spinal dorsal horn but are also operational in several regions processing the sensorimotor as well as emotional-affective components of pain, su

• The functionally crucial arginine within M is not encoded

  2022-07-11

  

  The functionally crucial arginine within M2 is not encoded by the gluR2 gene, but rather arises within the pre-mRNA by editing of a codon for the neutral glutamine residue25, 26. RNA editing at the Q/R site is specific to GluR2 and is extremely efficient. In neonatal and adult rat brain, almost 100%

• br Origin of the vertebrate hexokinase gene family Multiple

  2022-07-11

  

  Origin of the vertebrate hexokinase gene family Multiple hexokinases have been found in vertebrates, plants and yeast (Wilson, 1995, Cárdenas et al., 1998). A hexokinase in both vertebrates and yeast has, unfortunately, been named glucokinase. The sharing of the name glucokinase has suggested to

• It was previously proposed that glucagon

  2022-07-11

  

  It was previously proposed that glucagon acts in the liver, in which a signal is produced and relayed to the gsk-3 via vagal nerves [8], [36], [37]. The concept that the liver is the primary target site was supported by the studies reporting that the glucagon receptor is localized in the liver but

• Notwithstanding the functioning of galaninergic system

  2022-07-11

  

  Notwithstanding, the functioning of galaninergic system may be even more complex (Fuxe et al., 2012). Some studies present evidence that GAL2 receptors might form heteroreceptor complexes with neuropeptide Y1 receptors in az628 synthesis of amygdala (Narváez et al., 2015a), DRN (Díaz-Cabiale et al.

• Furthermore our results are the first to demonstrate that

  2022-07-11

  

  Furthermore, our results are the first to demonstrate that the stimulating effect of GALP on AVP release in rats is independent of galanin receptors. The same stimulatory GALP influence on AVP secretion has been also observed in the presence of galantide, an antagonist of Gal receptors in the incuba

• PBI is an agonist of GPR and

  2022-07-11

  

  PBI-4050 is an agonist of GPR40 and acts as an antagonist or inverse agonist of GPR84. It cannot be excluded that other targets besides GPR40 and GPR84 could be implicated in the mechanism of action of PBI-4050 and could be explored in future studies. However, the present study, and in particular th

• Free fatty acids FFAs which are obtained from dietary

  2022-07-11

  

  Free fatty acids (FFAs), which are obtained from dietary fat or endogenous synthesis, function as nutrients and signaling molecules. Studies have shown that free fatty WP1066 receptors 1–4 which are G-protein coupled receptors, bind free fatty acids and serve as receptors for these FFAs. Short chai

• Together the epigenetic interplay revealed in this study ena

  2022-07-08

  

  Together, the epigenetic interplay revealed in this study enabled us to expand the therapeutic potential of EZH2is from hematological malignances to solid tumors. In solid tumors, EZH2i-driven transcriptional changes are shown to be dispensable of H3K27me-regulated transcriptional network. Instead,

• br Conflict of interest br Acknowledgements This

  2022-07-08

  

  Conflict of interest Acknowledgements This work was funded by the University of Turin (ex60% 2014), World Wide Style Project (WWS; University of Turin/Fondazione CRT) and University of Florence (ex60% 2014). ACR and AP designed the study; AP, EB and IO conducted the literature search and analy

• Allergic rhinitis characterized by inflammation of the nasal

  2022-07-08

  

  Allergic rhinitis, characterized by inflammation of the nasal membrane, results from an over-activated immune system exposed to Ginkgolic Acid C15:1 mg in sensitized individuals, and is associated with nasal congestion, rhinorrhea, sneezing, and pruritus. As histamine is a key mediator in triggerin

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