• br Materials and methods br Results br

  2024-10-12

  

  Materials and methods Results Discussion Proteomics analyses generate mountains of data, expression information for hundreds or thousands of proteins in a single experiment (Wojcik and Schächter, 2000). Recently proteomics and bioinformatics provide new understandings about the processes in

• LY3009104 br Materials and methods br Results br Discussion

  2024-10-12

  

  Materials and methods Results Discussion CUs, which have been used as traditional medicine for thousands of years in East Asian countries, have the potential to be used for cancer chemoprevention and chemotherapy [17], [18], [19], [20]. CuB is one of the most promising agents as it is repor

• 5 alpha reductase inhibitor ATP citrate lyase ACLY is a cyto

  2024-10-12

  

  ATP citrate lyase (ACLY) is a cytosolic enzyme that catalyzes the generation of acetyl-CoA from citrate [15]. Acetyl-CoA is the building block for the biosynthesis of fatty acids and cholesterol, and also serves as a substrate of the acetylation reaction of various molecules, including histones and

• PHA-848125 On the other hand oxygen concentration in tumor t

  2024-10-12

  

  On the other hand, oxygen concentration in tumor tissue also depends on its consumption rate by tumor cells, which decrease will also lead to alleviation of hypoxia. This fact is not taken into account in the majority of studies on the topic, although it is well-known that antiangiogenic therapy doe

• These findings suggest that eventually more than one

  2024-10-11

  

  These findings suggest that eventually more than one 12/15-lipoxygenase isoform may play a role in human atherosclerosis. Humans have two 12-lipoxygenases and two 15-lipoxygenases which show different expression patterns, substrate specificities and stereo-selective metabolism [1]. However, in endot

• Modulating the ability of tumor cells to detoxify ROS is

  2024-10-11

  

  Modulating the ability of tumor Pyoluteorin to detoxify ROS is a key mechanism by which cysteine metabolism affects tumor cell survival. One study observed hypermethylation of cysteine dioxygenase (CDO1) in 60% of tested breast cancer samples, leading to increased ROS detoxification and tumor cell s

• br Acknowledgements br Introduction Diabetic complications

  2024-10-11

  

  Acknowledgements Introduction Diabetic complications are responsible for increased morbidity and mortality of diabetic patients. Increased flow of thymidylate synthase inhibitor through the polyol pathway under conditions of hyperglycemia contributes to the development of diabetic complicatio

• Ambient levels of ppm ozone were recorded during a recent

  2024-10-11

  

  Ambient levels of 0.2ppm ozone were recorded during a recent 2017 weather event in Texas, United States (EPA, 2007). This concentration or higher levels have been used in several human clinical studies during intermittent exercise (Miller et al., 2016c). Although ozone concentration of 0.8ppm used i

• br Adenosine and tumor microenvironment In the majority of

  2024-10-11

  

  Adenosine and tumor microenvironment In the majority of carcinogenic processes a proinflammatory state is generated [36], [37]. In addition, a tumor hypoxic environment is generally due to inadequate perfusion of oxygen to the tumor [38]. Immunomodulators are molecules that regulate the immune r

• In the presence of detrimental conditions such

  2024-10-11

  

  In the presence of detrimental conditions, such as inflammation, hypoxia, ischemia trauma or neoplastic milieu, the extracellular levels of adenosine increase massively, reaching micromolar range [51,52]. In these pathological contexts, adenosine accumulation stems from increased extracellular depho

• br AMPK structure and mechanism of action AMPK is a

  2024-10-11

  

  AMPK: structure and mechanism of action AMPK is a metabolic master switch that regulates downstream signals based on shifts in the surrounding energy reservoir [6]. It is expressed in a number of tissues, including the kidney, the liver, the skeletal muscle, the adipose tissue, and the hypothalam

• There has been growing interest over computational methods t

  2024-10-11

  

  There has been growing interest over computational methods to predict the biological activity by chemical structure, so as to decide whether it Pracinostat has objective qualities or not. In this contribution, the well-known method, which is called quantitative structure–activity relationship (QSAR)

• The zebrafish Danio rerio is a popular model organism

  2024-10-11

  

  The zebrafish (Danio rerio) is a popular model organism for virtually any biological function of vertebrates, and has, therefore, received a wide distribution in particular in developmental biology and toxicology (Strähle et al., 2012). With respect to AChE, the zebrafish has, e.g., been identified

• The small fishers with little or no quota

  2024-10-11

  

  The small fishers with little or no quota who remained relied on quota leasing arrangements to continue their fishing operations. Such arrangements had relatively high transaction costs and by early 2000 it appeared that the demise of the small fisher was imminent [2]. The introduction in 2001 of t

• Because activation of HT A receptor is capable of facilitati

  2024-10-11

  

  Because activation of 5-HT2A receptor is capable of facilitating dopamine cell activity and dopamine release (Bortolozzi et al., 2003), and this action of dopamine is known to mediate rat maternal behavior, especially maternal motivation (Afonso et al., 2007, Febo et al., 2010, Li and Fleming, 2003,

14522 records 35/969 page Previous Next First page 上5页 3132333435 下5页 Last page