• In agreement with the role of ACLY in

  2024-05-23

  

  In agreement with the role of ACLY in induced macrophage, we observe a drastically reduction of PGE2 levels when ACLY activity is inhibited. This is possible because PGE2 production requires arachidonic acid, which in turn is synthesized by elongation of dietary linoleic Difopein with acetyl-CoA pr

• Molecular docking quantitative structure activity relationsh

  2024-05-22

  

  Molecular docking, quantitative structure–activity relationship (QSAR) and high-throughput virtual screening (HTVS) studies have a very widespread use in computer-assisted drug design.25, 26, 27, 28 Suvannang et al. used the published X-ray crystallographic data to examine known aromatase inhibitors

• br Conclusions In summary aromatase mRNA expression

  2024-05-22

  

  Conclusions In summary, aromatase mRNA expression in the Azaserine australia of A. leptorhynchus shows a similar distribution pattern as seen in other teleosts with expression detected in the forebrain and the pituitary gland. The lack of aromatase mRNA expression in the midbrain and hindbrain o

• Hepatoid adenocarcinoma closely resembles HCC

  2024-05-22

  

  Hepatoid adenocarcinoma closely resembles HCC and in some cases can be indistinguishable morphologically. Hepatoid adenocarcinoma is an aggressive neoplasm, and metastasis to the liver is common [12]. Gastric metastasis from HCC has also been reported [27]. Distinguishing hepatoid adenocarcinoma fro

• In addition to calpain I

  2024-05-22

  

  In addition to calpain I activity, cathepsin activities have been proven to be linked to apoptotic signaling. Cathepsin B and cathepsin D are two of the most abundant and well-investigated lysosome acid-dependent proteases that are involved in the apoptotic regulation (Ferri & Kroemer, 2001). Cathep

• Wound healing without blastema formation

  2024-05-22

  

  Wound healing without blastema formation causes partial restoration of lost tissue, and gives rise to fibrotic scars. Healing by fibrotic scarring rather than by regeneration leads to tissue dysfunction, and can place a huge burden for the health of the animal [4]. Therefore, understanding the molec

• br Results and discussion The soil

  2024-05-22

  

  Results and discussion The soil fungus PSU-RSPG37 (BCC56870) was isolated from soil samples collected from Rajjaprabha Dam, Suratthani Province, Thailand. The fungus was deposited at BIOTEC Culture Collection, National Center for Genetic Engineering and Biotechnology (BIOTEC), Thailand Science Pa

• Thiazole heterocycles constitute an interesting class of

  2024-05-22

  

  Thiazole heterocycles constitute an interesting class of molecules, which exhibit a broad spectrum of biological activity, including antifungal properties [[16], [17], [18], [19]]. Encouraged by our previous study that describes the activity of hydrazine-thiazole derivatives against C. gattii and C.

• (S)-(+)-Dimethindene maleate br Antiangiogenic therapy in no

  2024-05-22

  

  Antiangiogenic therapy in non-small cell lung cancer (NSCLC) Antiangiogenic targeted therapy is an area of active research in which numerous agents have been studied and have been shown to be effective for many tumor types including NSCLC. Angiogenesis is frequently upregulated in malignant solid

• LOXs and CYPs are a series

  2024-05-22

  

  LOXs and CYPs are a series of iron-containing enzymes that metabolize arachidonic Fmoc-D-Phe(4-Cl)-OH to form biologically active products, such as epoxyeicosatrienoic acids (EETs) hydroperoxyeicosatetraenoic acids (HETEs), prostaglandins, leukotrienes and thromboxanes [6]. Among these mediators, 1

• Recently rather than predicting categorical variables as

  2024-05-22

  

  Recently, rather than predicting categorical variables as in classification, several studies begin to estimate continuous clinical variables from thiostrepton synthesis images. Therefore, instead of classify a subject into binary or multiple pre-determined categories or stages of the disease, regres

• br Introduction Psychostimulant abuse and

  2024-05-22

  

  Introduction Psychostimulant abuse and addiction remain a societal problem in the United States. The latest statistics from the National Survey on Drug Use and Health indicate that slightly less than one million people over the age of 12 report having a cocaine use disorder (NSDUH, 2016). Additio

• br Parkinson s Disease and the

  2024-05-22

  

  Parkinson’s Disease and the immune system Parkinson’s Disease (PD) is the second most common neurodegenerative disorder, after Alzheimer’s, which affects 10 million people globally and is characterized by rigidity, bradykinesia, tremors, and gait instability (O’sullivan et al., 2007). The patholo

• Because activation of HT A

  2024-05-22

  

  Because activation of 5-HT2A receptor is capable of facilitating dopamine cell activity and dopamine release (Bortolozzi et al., 2003), and this action of dopamine is known to mediate rat maternal behavior, especially maternal motivation (Afonso et al., 2007, Febo et al., 2010, Li and Fleming, 2003,

• In order to get a better understanding of this

  2024-05-22

  

  In order to get a better understanding of this synergy, we tested the effect of preliminary incubation of Digoxin with non-stimulating concentrations of gonadotropins or FSK before subsequent stimulation by FSK or gonadotropins alone, also at sub-stimulating concentrations. We observed that human L

15109 records 147/1008 page Previous Next First page 上5页 146147148149150 下5页 Last page